Nine years experiences of solid organ xenotransplantation
نویسندگان
چکیده
منابع مشابه
Posttransplantation lymphoproliferative disorder after pediatric solid organ transplantation: experiences of 20 years in a single center
PURPOSE To evaluate the clinical spectrum of posttransplantation lymphoproliferative disorder (PTLD) after solid organ transplantation (SOT) in children. METHODS We retrospectively reviewed the medical records of 18 patients with PTLD who underwent liver (LT) or kidney transplantation (KT) between January 1995 and December 2014 in Seoul National University Children's Hospital. RESULTS Eight...
متن کاملThe Role of Costimulation Blockade in Solid Organ and Islet Xenotransplantation
Pig-to-human xenotransplantation offers a potential bridge to the growing disparity between patients with end-stage organ failure and graft availability. Early studies attempting to overcome cross-species barriers demonstrated robust humoral immune responses to discordant xenoantigens. Recent advances have led to highly efficient and targeted genomic editing, drastically altering the playing fi...
متن کاملOvercoming immunologic barriers to discordant organ xenotransplantation
time, reduced ischemic injury) may counterbalance the poor HLA matching in the ULD group. Although the arguments against the use of living donors must be considered, long-term prospects for kidney donors is reassuring provided there is careful evaluation of potential donors and the strict criteria for exclusion are respected [2]. The benefit for the donor must also not be ignored. Our current p...
متن کاملActivation of cytomegalovirus in pig-to-primate organ xenotransplantation.
Xenotransplantation of porcine organs carries the risk of reactivation of latent virus in donor and recipient tissues as well as transmission of viruses between species. We have investigated the activation of baboon cytomegalovirus (BCMV) and porcine CMV (PCMV) in a pig-to-primate model of xenotransplantation. Tissues originating from a series of six swine-to-baboon composite thymokidney xenotr...
متن کاملGenetically Modified Pigs as Organ Donors for Xenotransplantation
The growing shortage of available organs is a major problem in transplantology. Thus, new and alternative sources of organs need to be found. One promising solution could be xenotransplantation, i.e., the use of animal cells, tissues and organs. The domestic pig is the optimum donor for such transplants. However, xenogeneic transplantation from pigs to humans involves high immune incompatibilit...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Korean Journal of Transplantation
سال: 2020
ISSN: 2671-8790,2671-8804
DOI: 10.4285/atw2020.po-1154